30 Medical Technologist Interview Questions (+ Sample Answers)

An interview can be a high-pressure assay of one’s career potential; ample preparation sets the stage for a confident performance. For medical technologists, it’s a vital step where skill and personability are measured with every answer given.

  • For Candidates, this article is a carefully calibrated instrument designed to help you articulate your qualifications and passion for the field.
  • For Interviewers, our curated questions and answers will serve as a guide to assess the technical acumen and problem-solving mettle of your potential hires.
  • For Mentors and Coaches, the insights provided herein will enable you to sculpt the narratives of the candidates you support, ensuring they can effectively convey their skills and suitability for the role.

In this article, we distill essential questions and provide sample answers to empower all involved in the medical technologist interview process.

Table of Contents


Skill-Level Determiner Questions

1. Describe the process you follow when performing a complete blood count (CBC). What steps do you take to ensure accuracy?

This question tests the candidate’s familiarity with basic hematology testing and assesses their attention to detail, which is crucial for producing accurate and reliable results.

A good answer should include:

  • Outline the steps clearly, demonstrating knowledge of the procedure.
  • Mention quality control checks, such as using control samples.
  • Explain how to interpret common issues or flags that analyzers might report.
Sample Answer:

"When conducting a Complete Blood Count (CBC), I first confirm the patient’s identity and adhere to proper specimen collection protocols. I then prepare the automated analyzer, confirming its calibration and quality control status. 

Throughout the analysis, I watch for errors or abnormalities, addressing any issues such as clotting. Finally, I validate the results against historical data and reference ranges, and if necessary, conduct a peripheral blood smear for further examination."

2. What precautions do you take to avoid contamination or degradation of specimens during collection and handling?

This question assesses a candidate’s awareness of proper specimen handling procedures and commitment to maintaining the highest laboratory practice standards.

A good answer should include:

  • Discuss the use of appropriate protective equipment and sterile techniques.
  • Explain the handling of specimens in a timely manner and proper storage conditions.
  • Emphasize adherence to OSHA and other relevant guidelines and protocols.
Sample Answer:

"To prevent contamination or degradation, I always wear appropriate PPE such as gloves and lab coats and use sterilized collection tools. I handle specimens promptly to avoid prolonged exposure to environmental factors that can affect their integrity. 

For example, blood samples for certain analytes should be kept at room temperature and processed quickly, while others need to be chilled. I ensure proper labeling to avoid mix-ups and store each specimen according to its specific requirements, following our lab's SOPs and the latest OSHA guidelines."

3. Describe the procedure for labeling, storing, and transporting specimens in the laboratory. How does this maintain specimen integrity?

This question gauges a candidate’s understanding of the logistical aspects of specimen management and their ability to prevent pre-analytical errors.

A good answer should include:

  • Illustrate the importance of correct labeling practices.
  • Hone in on specific storage conditions for different types of specimens.
  • Highlight the use of secure containers for transport to prevent spills or cross-contamination.
Sample Answer:

"The process begins with careful labeling at the point of collection, where I make sure all specimens are clearly marked with patient identifiers, the type of specimen, and the time of collection. 

In storage, I adhere to the required temperature conditions and timelines, whether it's refrigeration or freezing, to maintain specimen viability. 

For transport, I use sealed biohazard bags and properly secured, durable containers to prevent accidents, and I personally ensure that each specimen is logged into our tracking system for accountability and traceability."

4. How do you ensure the integrity of a specimen from collection to processing?

This question examines a candidate’s ability to adhere to protocols that prevent pre-analytical errors, which are vital for reliable laboratory outcomes.

A good answer should include:

  • Detail specific handling procedures for different specimen types.
  • Reference the use of control measures and checks at different stages.
  • Discuss the importance of consistent communication with other healthcare professionals involved in sample collection and processing.
Sample Answer:

"To maintain specimen integrity, I use proper tubes and collection sequences, check supply expiration dates, and ensure patient information matches the paperwork. I transport and store samples carefully to preserve quality and continuously confirm accuracy against lab requisitions."

5. Describe the steps you take when performing a crossmatch test prior to a blood transfusion.

This question assesses the candidate’s understanding of immunohematology protocols and their ability to perform meticulous work vital for patient safety.

A good answer should include:

  • Explain the importance of patient and donor sample verification.
  • Describe the technical steps of the crossmatch in detail.
  • Discuss the actions taken in case of an incompatible result.
Sample Answer:

"I initiate a crossmatch by confirming the correct labeling of patient and donor samples. I conduct an immediate spin test, followed by an antiglobulin phase to check for incompatibility signs like agglutination or hemolysis. 

Adhering to strict protocols, I record results meticulously and communicate any incompatibilities to the physician for patient safety."

6. Explain the importance of antibody screening in transfusion medicine, and describe a situation where you had to perform this task.

This question assesses the candidate’s depth of knowledge in immunohematology and ability to identify and interpret unexpected antibodies in the blood.

A good answer should include:

  • Outline the purpose of antibody screening in the prevention of transfusion reactions.
  • Discuss the methodology for identifying unexpected antibodies.
  • Reflect on the implications of antibody identification for patient care.
Sample Answer:

"Antibody screening is crucial for detecting atypical antibodies that may cause adverse reactions during transfusions. I use the indirect antiglobulin test to screen patients' serum against reagent red cells with known antigen profiles. 

In one instance, I identified an unexpected antibody in a patient's sample, which was initially serologically characterized and then further defined through additional testing. 

My findings allowed the blood bank to provide antigen-negative blood for the patient, preventing a potential hemolytic reaction. Such vigilance ensures optimal patient care by tailoring transfusions to their specific immunological needs."

Other Skill-Level Determiner Questions:

  • When performing antibiotic sensitivity testing, what factors do you consider when interpreting the results?
  • What process do you follow when verifying the validity of an outlier result in a set of data?
  • How would you manage a situation where a specimen’s validity is in question due to collection or handling errors?

Behavioral-Based Questions

1. Have you ever identified a trend or pattern in lab results that was unusual or concerning? How did you address it, and what was the outcome?

This question gauges the candidate’s analytical skills and ability to notice discrepancies that could affect patient care or public health.

A good answer should include:

  • Describe the specific trend or pattern you observed.
  • Discuss the steps you took to address the situation.
  • Highlight the outcome and any positive effects on patient care or lab operations.
Sample Answer (STAR Method): 

"In a previous role, I encountered a situation where there was an unusual surge in patients with a specific strain of antibiotic-resistant bacteria. Acting in adherence to protocols, I promptly reported my findings to the supervising pathologist and the healthcare team. 

Following this, a collaborative effort was initiated to delve into the patients' histories, revealing a commonality—they had all undergone the same surgical procedure. This discovery pointed to a breach in sterile techniques within the operating room. 

Working collectively to rectify this issue, we implemented corrective measures that resulted in a significant decrease in similar incidents, thereby enhancing overall patient safety."

2. How have you coped with a rapidly evolving situation in the lab, such as an outbreak of an infectious disease or a public health emergency requiring urgent testing?

This question assesses the candidate’s ability to adapt to high-pressure situations and their experience managing urgent, large-scale testing procedures, which may be critical during a public health crisis.

A good answer should include:

  • Mention any specific strategies you used to manage the increased workload.
  • Highlight your ability to stay calm and focused.
  • Describe the impact of your actions on the situation, colleagues, and patients.
Sample Answer (STAR Method): 

"Amid the recent COVID-19 outbreak, our laboratory experienced a substantial increase in workload. In response, I strategically prioritized tasks, willingly volunteered for additional shifts, and underwent cross-training on various test types to provide essential backup for my colleagues. 

This proactive approach and collaborative teamwork were pivotal in ensuring that we efficiently met the escalating testing demands, contributing significantly to patient management and public health monitoring."

3. Can you talk about a time when you had to present complex data or findings to a group with varied levels of understanding. How did you ensure your message was clearly conveyed?

This question evaluates the candidate’s communication skills and their ability to break down complex technical information into understandable terms for individuals who may not possess a scientific background.

A good answer should include:

  • Discuss your approach to tailoring information to different audiences.
  • Describe how you used visuals or analogies to make the information more relatable.
  • Reflect on the feedback you received to indicate your success in effectively communicating the data.
Sample Answer (STAR Method): 

"In a notable instance, I delivered a presentation on drug-resistant bacteria during a hospital-wide meeting. Recognizing the diverse audience, spanning from administrative staff to medical professionals, I employed a communication strategy focused on clarity and accessibility. 

To make the information relatable, I utilized clear visuals, avoided technical jargon, and drew analogies, likening bacterial resistance to a lock and key system where the bacteria acted as the lock changers. Post-presentation surveys indicated that attendees found the information accessible and engaging."

4. Reflect on a challenging case where your initial test results were inconclusive or unexpected. How did you proceed to obtain a definitive result?

This question assesses the medical technologist’s problem-solving skills and their persistence in achieving accurate results, crucial for patient diagnosis and treatment decisions.

A good answer should include:

  • Describe your diagnostic reasoning and the additional steps you took to resolve the issue.
  • Show your commitment to quality and accuracy in your work.
  • Exhibit your knowledge of the appropriate use of different testing modalities.
Sample Answer (STAR Method): 

"When confronted with inconclusive results from initial screens for a suspected viral infection, I engaged in a collaborative decision-making process with our pathologist to explore alternative testing strategies. Together, we opted for polymerase chain reaction (PCR) assays, complemented by repeat samples over several days. 

The PCR results confirmed the presence of the virus, enabling the healthcare team to initiate the correct course of treatment. This experience underscored the significance of persistence and thoroughness in diagnostic processes."

5. Discuss an instance when you contributed to creating or modifying a lab protocol or SOP. What prompted the change, and how did you go about it?

This question aims to assess the candidate’s experience and capability in protocol development or modification, offering insights into their ability to identify areas for improvement and actively contribute to advancing laboratory efficiency and accuracy.

A good answer should include:

  • Explain the reason behind the need for a new or revised protocol/SOP.
  • Detail the process of how you approached the modification or creation.
  • Highlight the benefits or improvements that resulted from the change.
Sample Answer (STAR Method): 

"Observing recurring discrepancies in our CBC reports, I undertook a data-driven approach to identify patterns and proposed a revision to our Standard Operating Procedure (SOP) for calibrating the hematology analyzer. 

Specifically, I recommended the inclusion of additional quality control checks each morning. Presenting these proposed changes to our lab director, I outlined the potential improvements in accuracy. 

Following the implementation of these changes, we observed a notable reduction in discrepancies, ultimately leading to more reliable reports that positively impacted patient care."

Other Behavioral-Based Questions:

  • Share an example of how you handle the stress of a demanding workload while still maintaining a high standard of accuracy in your work.
  • Describe a time when you were tasked with performing tests under a strict deadline. How did you ensure the timeliness without compromising on the quality of the results?
  • Tell us about a time you had to work with a challenging specimen and how you ensured accurate test results.

Situational-Based Questions

1. Picture yourself working on a critical project that requires collaboration with other departments, and you encounter resistance or lack of cooperation from some team members. What steps would you take to ensure the success of the project?

This question assesses the candidate’s interpersonal skills, problem-solving abilities, and leadership potential.

A good answer should include:

  • Highlight the importance of clear communication and understanding different perspectives.
  • Discuss the value of setting shared goals and aligning the team towards a common objective.
  • Mention strategies like mediation or conflict resolution to address any resistance.
Sample Answer: 

"To ensure the project's success, I would first seek to understand the reasons behind the resistance by directly communicating with the team members involved. I’d arrange a meeting to discuss our common goals and how collaboration benefits both departments. 

If the issue persists, I’d propose a mediated session with a supervisor to resolve conflicts and find a productive path forward."

2. Imagine a physician calls you, frustrated with a lab result that seems inconsistent with their patient’s symptoms. How would you handle this conversation, and how would you proceed to address their concerns?

This question measures the candidate’s communication skills, customer service orientation, and ability to manage stressful situations calmly and professionally.

A good answer should include:

  • Display an understanding of the importance of active listening and empathy to validate the physician’s concerns.
  • Show knowledge of laboratory procedures for verifying results and the steps involved in investigating discrepancies.
  • Emphasize the commitment to patient care and the role of teamwork between the laboratory and medical staff.
Sample Answer: 

"I would listen to the physician attentively, ensuring they feel heard, and then calmly explain the validation process our results go through. I’d reassure them that I’ll review the test, looking into quality control records and re-processing the sample if necessary. I'd follow-up with the physician to discuss the findings and next steps."

3. Imagine you’re involved in a clinical trial and the preliminary results are not aligning with expected outcomes. How would you proceed in verifying the data and potentially re-evaluating the testing procedures?

This question examines the candidate’s analytical skills, attention to detail, and ability to adhere to scientific rigor in the face of unexpected results.

A good answer should include:

  • Stress the importance of confirming the accuracy of initial results with repeat tests or additional quality controls.
  • Describe how you would document all procedures and findings to ensure transparent scientific methods.
  • Suggest a willingness to consult with peers or supervisors to gain further insight or guidance if discrepancies persist.
Sample Answer: 

"I would initiate a thorough review of the testing procedures, re-test critical samples, and cross-check our methods with the trial protocols. I'd document each step for accountability and consult the principal investigator for additional insights. Transparency and a methodical approach are key to resolving such issues."

4. If a series of test results point to a possible contamination issue within the lab, how would you investigate and address the potential contamination source?

This question assesses the candidate’s proficiency in quality control measures and ability to resolve critical issues impacting lab operations and patient safety.

A good answer should include:

  • Highlight knowledge of contamination identification techniques and standard procedures for addressing lab contamination issues.
  • Discuss the systemic approach required for such investigations, including how to isolate possible sources and take corrective measures.
  • Stress the importance of preventative strategies and ongoing education to minimize future risks.
Sample Answer: 

"Upon suspecting contamination, I would act swiftly to halt testing and initiate a root-cause analysis, reviewing recent changes in procedures, reagents, or equipment. Appropriate steps include re-testing, sterilization, and possibly discarding affected materials. Post-incident, I’d update protocols and educate staff to prevent recurrence."

5. If you are responsible for presenting a portion of your laboratory’s quality assurance data during an accreditation visit, how would you prepare and present this information to ensure it accurately reflects the lab’s standards and practices?

This question evaluates the candidate’s understanding of regulatory standards, quality assurance practices, and their ability to represent the laboratory’s adherence to high professional standards.

A good answer should include:

  • Discuss the process for compiling, analyzing, and summarizing quality assurance data in an accessible format for reviewers.
  • Mention the significance of aligning the presentation with accreditation standards and the lab’s quality objectives.
  • Reveal an anticipation for potential questions and the preparation of comprehensive answers that reflect the data’s implications.
Sample Answer: 

"I would ensure that all data is up to date, thoroughly analyzed, and presented in graphs or charts for clarity. I'd familiarize myself with accreditation guidelines to align our data with those standards. During the presentation, I would be transparent, provide context for the data, and be ready to answer questions thoroughly."

Other Situational Questions:

  • Imagine you receive a lab result that has critical values which could indicate a life-threatening situation for a patient. How would you handle this situation, and what steps would you take to ensure the proper individuals are notified promptly?
  • How would you proceed if you identified a significant and unusual trend in the results coming from a species of bacteria that is typically considered non-pathogenic?
  • Imagine you receive conflicting test results for a critical patient. How would you handle the situation and ensure the accuracy of the results?

Organizational Fit Questions

1. How do you handle stress and prevent burnout while maintaining a high quality of work in a fast-paced lab environment?

This question is crucial because it assesses the candidate’s resilience and ability to maintain performance under pressure, which is common in clinical lab settings.

A good answer should include:

  • Mention practical stress management techniques that you’ve found effective.
  • Discuss the importance of maintaining work-life balance.
  • Emphasize the role of support systems, whether they be colleagues, superiors, or external resources.
Sample Answer: 

"To handle stress, I prioritize tasks and break down large projects into manageable parts. I maintain open communication with superiors if timelines seem unrealistic, ensuring the quality is not compromised. 

Additionally, I engage in regular physical activity and make sure to spend time unwinding with family, which helps prevent burnout."

2. How do you stay motivated in a job that can be routine at times, and what do you do to keep your skills sharp?

This question evaluates how a candidate finds personal fulfillment in their work and their commitment to continuous improvement—a key aspect of healthcare professions where technology and methodologies constantly evolve.

A good answer should include:

  • Highlight commitment to lifelong learning, whether through continuing education or professional workshops.
  • Share experiences or strategies for setting personal goals or seeking new challenges within the routine.
  • Reflect on past accomplishments and how they remind you of the job’s impact and motivate you to continue performing well.
Sample Answer: 

"Staying up-to-date with the latest advancements through webinars and journals keeps me motivated and enhances my practice. On a routine day, setting micro-goals for improving efficiency brings a sense of achievement. I also volunteer to train new staff, which refreshes my skills and provides a rewarding break from the routine."

3. Communication is key in our lab. How do you ensure effective communication with your peers, especially under stressful circumstances?

This question probes the candidate’s ability to interact constructively with colleagues despite high tensions.

A good answer should include:

  • Discuss the importance of active listening and open dialogue in a team.
  • Mention how you stay calm and collected, even in high-pressure situations.
  • Reflect on specific tools or methods like structured handovers or checklists to ensure nothing is missed during communication.
Sample Answer: 

"Under stress, I focus on clear and concise communication. I listen carefully, summarize key points to confirm understanding, and document discussions when necessary. 

I've found that staying composed and approaching conflicts as team challenges to solve, rather than personal issues, leads to more effective problem solving and collaboration."

Other Organizational Fit Questions:

  • How do you approach situations where you have to work with someone who has a different work style than you do?
  • How do you demonstrate responsibility and accountability in your daily tasks as a Medical Technologist?

Job Interview Tips

  • Be prepared to discuss your educational background, certifications, and work experiences in detail. Highlight any techniques or technologies you are proficient in, and be ready to share experiences demonstrating your expertise.
  • Refresh your knowledge of fundamental medical laboratory techniques, common tests, procedures, and recent industry developments. Be prepared to discuss how you conduct specific assays or handle laboratory equipment.
  • Be aware of the latest developments in medical technology, as this will showcase your commitment to staying up-to-date in your field. Discuss them when appropriate if you have experience or knowledge of cutting-edge practices or technologies.
  • Research the facility you’re interviewing with. Understand their specialties, the types of tests they frequently perform and their patient population. This will enable you to tailor your responses to show how your skills and experiences align with their needs.

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Brenda Calisaan is a psychology graduate who strongly desires to impact society positively. She aspires to spread awareness and knowledge about mental health, its importance, and its impact on individuals and society.

She also has a passion for working with children and hopes to dedicate her career to positively impacting their lives.

Outside of work, Brenda is an avid traveler and enjoys exploring new experiences. She is also a music enthusiast and loves to listen to a variety of genres. When she's not on the road or working, Brenda can often be found watching interesting YouTube videos, such as Ted-Ed content.